Which of the following is a key feature of protein synthesis in the rough ER?

The key feature of protein synthesis in the rough endoplasmic reticulum (rough ER) is the modification and folding of proteins. The rough ER is studded with ribosomes on its cytoplasmic surface, which gives it a "rough" appearance. These ribosomes are the sites of protein synthesis, where amino acids are assembled into polypeptide chains based on the genetic instructions carried by messenger RNA (mRNA).

As proteins are synthesized on the ribosomes of the rough ER, they enter the lumen of the rough ER where they undergo several important modifications. These modifications often include glycosylation, where carbohydrate groups are added to the protein, as well as folding into their three-dimensional shapes, which is crucial for their functionality. Additionally, chaperone proteins within the ER lumen assist in the proper folding and assembly of these newly synthesized proteins.

The function of the rough ER in the modification and folding of proteins is critical to ensuring that proteins are correctly processed before they are transported to their final destinations within or outside the cell. This is a fundamental aspect of protein trafficking, emphasizing the importance of the rough ER in the secretory pathway.

In contrast, storage of genetic information pertains to the cell nucleus, energy production is primarily associated with mitochond